Target intelligence / Profile preview

Poly [ADP-ribose] polymerase 15 (PARP15)

Target: PARP15
Molecular classification: Enzyme, Mono-ADP-ribosyltransferase, Macro-domain containing protein

Overview

Poly [ADP-ribose] polymerase 15 (PARP15) is a member of the PARP family of proteins, which modify target proteins by ADP-ribosylation, a reversible post-translational modification using NAD+ as a substrate[1][2][4]. PARP15 is characterized by the presence of a macro domain and catalyzes mono-ADP-ribosylation (not poly)[2][4]. Its physiological functions are poorly understood, but PARP15 is grouped within the “macro-PARP” subfamily (alongside PARP9 and PARP14), suggesting possible regulatory roles in transcription and immune signaling, as well as associations with cancer development or prognosis[2][4]. Structural and inhibitor studies exist, but no clinically approved drugs are specific for PARP15, and its role as a pharmacological target remains mostly exploratory[3][2][4].

Other names: BAL3Protein mono-ADP-ribosyltransferase PARP15

Mechanism of action

Inhibition of mono-ADP-ribosylation activity; Modulation of apoptosis (inferred from inhibitor studies in cells)

Biological functions

ADP-ribosylation (mono-ADP-ribosyltransferase activity)Postulated involvement in the regulation of transcription (by homology to PARP9 and PARP14)Uncharacterized cellular functions (no clear function defined in literature)

Disease associations

Cancer (association or correlative genetic studies in some malignancies, including polymorphisms linked to prognosis in acute myeloid leukemia and lung adenocarcinoma)

Safety considerations

Not established; safety profile largely unknown due to lack of clinical development

Interacting drugs

OUL221

1 more in the full profile.

Biomarkers

Genetic polymorphisms (e.g., rs6793271, rs17208928) associated with clinical outcomes in cancer

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